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KMID : 0379520230390040749
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한국독성학회지
2023 Volume.39 No. 4 p.749 ~ p.759
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Effects of grape seed proanthocyanidin extract on side effects of high-dose methylprednisolone administration in male rats
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Aslihan Sur
Seda Iflazoglu Mutlu
Pinar Tatli Seven
Ismail Seven
Abdullah Aslan
Meltem Kizil
Recai Kulaksiz
Mustafa Hilmi Yaranoglu
Selim Esen
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Abstract
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In this study, we investigated the effects of grape seed proanthocyanidin extract (GSPE) against the side effects of high-dose administration of methylprednisolone (MP) in male rats. A total of 32 adult Wistar male albino rats were divided into four groups: (1) control (CON), received standard food only; (2) MP, received standard food?+?intraperitoneal injection of 60 mg/kg MP on day 7; (3) GSPE, received standard food?+?200 mg/kg/day GSPE; and (4) MP?+?GSPE, received standard food?+?200 mg/kg/day of GSPE?+?intraperitoneal injection of 60 mg/kg MP on day 7. All animals in the GSPE and GSPE?+?MP groups were treated once a day by oral gavage for 14 consecutive days. The feed intake of rats in the MP and MP?+?GSPE groups decreased significantly by 24.14% and 13.52%, respectively (p?
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KEYWORD
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Grape seed proanthocyanidin extract, Methylprednisolone, Apoptosis, Biomarker, Sperm characteristic
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